Description

5-Acetyl-2-(4-Fluorophenoxy)-6-Methylnicotinonitrile is a specialized organic compound featuring a nicotinonitrile core substituted with acetyl, methyl, and fluorophenoxy groups. This molecular architecture makes it a valuable advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders or metabolic diseases.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides or fungicides, leveraging the fluorophenoxy moiety.
• Chemical Biology Probes: Can be utilized to create tool compounds for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	5-Acetyl-2-(4-Fluorophenoxy)-6-Methylnicotinonitrile
CAS No.	303146-68-1
Molecular Formula	C15H11FN2O2
Molecular Weight	270.26 g/mol
Synonyms	5-Acetyl-2-(4-fluorophenoxy)-6-methylnicotinonitrile; 2-(4-Fluorophenoxy)-6-methyl-5-acetylnicotinonitrile; 5-Acetyl-2-(p-fluorophenoxy)-6-methyl-3-pyridinecarbonitrile; 303146-68-1; Nicotinonitrile, 5-acetyl-2-(4-fluorophenoxy)-6-methyl-; 6-Methyl-5-acetyl-2-(4-fluorophenoxy)nicotinonitrile
EINECS	Contact for details

Quality Control

Our production of 5-Acetyl-2-(4-Fluorophenoxy)-6-Methylnicotinonitrile adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.