Description

5-Acetyl-2-[(2-Chlorophenyl)Sulfanyl]-6-Methylnicotinonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique nicotinonitrile core functionalized with acetyl and chlorophenylsulfanyl groups. This compound is of significant commercial value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the research and development of new drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Serves as a versatile scaffold for creating novel pesticides and herbicides, leveraging its heterocyclic structure for biological activity.
• Chemical Research & Development: Used in academic and industrial R&D labs for exploring new chemical entities (NCEs) and studying structure-activity relationships (SAR).
• Material Science: Potential application as a monomer or additive in the synthesis of specialized polymers and advanced organic materials.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	5-Acetyl-2-[(2-Chlorophenyl)Sulfanyl]-6-Methylnicotinonitrile
CAS No.	303146-65-8
Molecular Formula	C15H11ClN2OS
Molecular Weight	302.78 g/mol
Synonyms	5-Acetyl-2-[(2-chlorophenyl)thio]-6-methylnicotinonitrile; 2-[(2-Chlorophenyl)thio]-5-acetyl-6-methyl-3-pyridinecarbonitrile; 5-Acetyl-2-(2-chlorophenylthio)-6-methyl-3-cyanopyridine; 6-Methyl-5-acetyl-2-(2-chlorophenylthio)nicotinonitrile; 303146-65-8; 5-Acetyl-2-(2-chlorophenylsulfanyl)-6-methylnicotinonitrile
EINECS	Contact for details

Quality Control

Our 5-Acetyl-2-[(2-Chlorophenyl)Sulfanyl]-6-Methylnicotinonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.