Description

Benzoic Acid, 2-Hydroxy-3-(Trifluoromethyl)-, Methyl Ester is a specialized fluorinated aromatic ester that serves as a high-value synthetic intermediate. Its core value proposition lies in the unique combination of the trifluoromethyl group, which imparts enhanced lipophilicity and metabolic stability, and the versatile benzoate ester functionality. This compound is critically needed by R&D and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. Its structural features make it a key building block for creating compounds with improved biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances bioactivity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), contributing to improved performance and stability.
• Polymer Modification: Acts as a monomer or modifier in specialty polymer chemistry to introduce fluorine atoms, thereby altering surface properties, chemical resistance, and durability of the final material.
• Organic Synthesis & Catalysis: Employed as a versatile reagent in academic and industrial research for constructing complex molecular architectures, including in cross-coupling reactions and as a ligand precursor.
• Dye & Pigment Industry: Utilized in the synthesis of specialized fluorinated dyes and pigments that offer superior lightfastness and unique color properties.

Basic Information

Product Name	Benzoic Acid, 2-Hydroxy-3-(Trifluoromethyl)-, Methyl Ester
CAS No.	302608-06-6
Molecular Formula	C9H7F3O3
Molecular Weight	220.15 g/mol
Synonyms	Methyl 2-Hydroxy-3-(trifluoromethyl)benzoate; 2-Hydroxy-3-(trifluoromethyl)benzoic Acid Methyl Ester; 3-(Trifluoromethyl)salicylic Acid Methyl Ester; Methyl 3-(Trifluoromethyl)salicylate; Salicylic Acid, 3-(Trifluoromethyl)-, Methyl Ester; 2-Hydroxy-3-trifluoromethyl-benzoic Acid Methyl Ester; 302608-06-6; Methyl 2-hydroxy-α,α,α-trifluoro-m-toluate
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 2-Hydroxy-3-(Trifluoromethyl)-, Methyl Ester is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing specifications such as assay, impurity profile, and physical characteristics are provided with every shipment. We support compliance with relevant frameworks including cGMP where applicable for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. Ensure the storage area is free from excessive heat and ignition sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.