Description

4-(Pyrazin-2-Ylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperidine derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its core value lies in providing a versatile, nitrogen-rich scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working in the pharmaceutical, agrochemical, and fine chemical industries who require reliable access to high-purity building blocks for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its modifiable piperidine and pyrazine rings.
• Library Synthesis: Employed in the parallel and combinatorial synthesis of diverse compound libraries for high-throughput screening (HTS) against novel biological targets.
• Peptidomimetic Development: Serves as a constrained surrogate for amino acids in the design of novel peptidomimetics and protease inhibitors.
• Agrochemical Synthesis: Acts as a precursor in the development of new herbicides, fungicides, and insecticides that utilize heterocyclic amine motifs.
• Ligand and Catalyst Preparation: Utilized for synthesizing novel chelating ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	4-(Pyrazin-2-Ylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	301226-90-4
Molecular Formula	C14H22N4O2
Molecular Weight	278.35 g/mol
Synonyms	1-Boc-4-(pyrazin-2-ylamino)piperidine; tert-Butyl 4-[(pyrazin-2-yl)amino]piperidine-1-carboxylate; N-Boc-4-(2-pyrazinylamino)piperidine; 4-(Pyrazin-2-ylamino)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(pyrazin-2-ylamino)piperidine; Boc-4-(2-pyrazinylamino)piperidine; 4-(2-Pyrazinylamino)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; Piperidine-1-carboxylic acid, 4-[(2-pyrazinyl)amino]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 4-(Pyrazin-2-Ylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled and stored accordingly to maintain stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.