Description

tert-Butyl 2-Oxo-1-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic lactam-oxazolidinone structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within therapeutic areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates and novel APIs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing spirocyclic and fused heterocyclic libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: Used in the research and synthesis of potential inhibitors targeting various protease enzymes.
• Chemical Biology Probes: Employed as a core structure for developing molecular probes to study biological pathways and enzyme functions.
• Process Chemistry & Scale-Up: Provides a reliable and well-defined starting material for process optimization and pilot-scale production of target molecules.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) specializing in complex organic molecules.

Basic Information

Product Name	tert-Butyl 2-Oxo-1-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylate
CAS No.	301226-27-7
Molecular Formula	C13H21NO4
Molecular Weight	255.31 g/mol
Synonyms	8-Boc-2-oxo-1-oxa-8-azaspiro[4.5]decane; tert-Butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; 1-Oxa-8-azaspiro[4.5]decane-2-one, 8-(1,1-dimethylethoxy)carbonyl]-; 8-(tert-Butoxycarbonyl)-2-oxo-1-oxa-8-azaspiro[4.5]decane; Boc-1-oxa-8-azaspiro[4.5]decan-2-one; 2-Oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 2-Oxo-1-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested against rigorous in-house specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.