Description

Methyl L-Threoninate Hydrochloride is a protected amino acid derivative essential for advanced organic synthesis and peptide research. This high-purity building block is critical for ensuring the stereochemical integrity and yield of complex target molecules. It is primarily utilized by pharmaceutical R&D teams, peptide synthesis specialists, and fine chemical manufacturers developing novel therapeutic agents and biochemical tools.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the threonine residue with a protected carboxyl group.
• Biochemical Research: Employed in the study of enzyme-substrate interactions, protein structure, and the development of enzyme inhibitors.
• Protecting Group Strategy: The methyl ester serves as a versatile protecting group that can be selectively cleaved under specific conditions during multi-step syntheses.
• Fine Chemical Production: A precursor in the manufacture of specialized agrochemicals, flavors, and fragrances requiring high enantiomeric purity.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in GMP environments.

Basic Information

Product Name	Methyl L-Threoninate Hydrochloride
CAS No.	39994-75-7
Molecular Formula	C5H12ClNO3
Molecular Weight	169.61 g/mol
Synonyms	L-Threonine methyl ester hydrochloride; (2S,3R)-2-Amino-3-hydroxybutyric acid methyl ester hydrochloride; Methyl (2S,3R)-2-amino-3-hydroxybutanoate hydrochloride; H-Thr-OMe·HCl; Methyl L-threonine hydrochloride; Threonine methyl ester HCl; Methyl (2S,3R)-3-hydroxy-2-aminobutanoate hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl L-Threoninate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	Contact for details
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.