Description

H-Asp(Otbu)-Ome is a protected aspartic acid derivative, specifically the tert-butyl ester of aspartic acid β-methyl ester. This compound serves as a crucial building block (amino acid derivative) in the synthesis of complex peptides and pharmaceutical intermediates. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and bioactive compounds.

Application

• Pharmaceutical Intermediate: Key raw material in the solid-phase and solution-phase synthesis of peptide-based drugs and APIs.
• Peptide Synthesis Building Block: Used to incorporate aspartic acid residues into peptide chains while protecting the side-chain carboxylic acid group.
• Research & Development: Essential reagent in medicinal chemistry for structure-activity relationship (SAR) studies and novel compound library generation.
• Bioconjugation: Serves as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Fine Chemical Synthesis: Intermediate for synthesizing specialized amino acid analogs, enzyme inhibitors, and other bioactive molecules.

Basic Information

Product Name	H-Asp(Otbu)-Ome
CAS No.	39895-10-8
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	L-Aspartic acid, 1-(1,1-dimethylethyl) 4-methyl ester; Aspartic acid β-tert-butyl ester α-methyl ester; H-Asp(OtBu)-OMe; (2S)-2-Amino-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid methyl ester; Methyl (2S)-2-amino-4-[(tert-butoxy)carbonyl]butanoate; Boc-Asp-OMe (common misnomer, correct for Boc-protected); Fmoc-Asp(OtBu)-OH precursor; Protected Aspartic Acid Derivative
EINECS	Contact for details

Quality Control

Our H-Asp(Otbu)-Ome is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.