Description

1α,2α-Bis[(Trimethylsilyl)Oxy]Cyclohexane CAS NO 39789-20-3 is a specialized organosilicon compound featuring a cyclohexane ring protected by two trimethylsilyl (TMS) ether groups. This compound serves as a valuable protected intermediate and silylating agent in advanced organic synthesis, offering enhanced stability and reactivity control for sensitive transformations. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of complex molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly where protection of diol functionalities is required.
• Silylation Reagent: Used to introduce trimethylsilyl groups onto hydroxyl-containing compounds, altering their solubility and volatility for analytical or synthetic purposes.
• Asymmetric Synthesis: Employed as a chiral auxiliary or protected chiral synthon in stereoselective reactions to construct complex molecular architectures.
• Polymer Chemistry: Monomer or modifier in the production of specialty silicones and silicon-containing polymers.
• Material Science: Precursor for surface modification of silica-based materials or for creating organic-inorganic hybrid composites.
• Analytical Chemistry: Derivatization agent for gas chromatography (GC) analysis of compounds with hydroxyl groups to improve thermal stability and detection.

Basic Information

Product Name	1α,2α-Bis[(Trimethylsilyl)Oxy]Cyclohexane
CAS No.	39789-20-3
Molecular Formula	C12H28O2Si2
Molecular Weight	260.52 g/mol
Synonyms	1,2-O-Bis(trimethylsilyl)cyclohexane-1,2-diol; cis-1,2-Bis(trimethylsiloxy)cyclohexane; Cyclohexane-1,2-diol, 1,2-bis(trimethylsilyl) ether; 1,2-Bis-O-(trimethylsilyl)cyclohexane-1,2-diol; 1,2-Bis(trimethylsiloxy)cyclohexane; TMS-protected cyclohexane-1,2-diol; (1R,2R)-1,2-Bis(trimethylsilyloxy)cyclohexane (for stereoisomer); BTMSC
EINECS	Contact for details

Quality Control

Our 1α,2α-Bis[(Trimethylsilyl)Oxy]Cyclohexane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and industrial synthesis. All products undergo rigorous analytical testing, including GC, HPLC, and NMR, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.