Description

[(17-Methyl-5α-Androstane-3β,17β-Diyl)Bis(Oxy)]Bis(Trimethylsilane) is a high-purity, organosilicon-protected steroid derivative, specifically designed as a critical synthetic intermediate. This compound is valued for its role in introducing silyl ether protecting groups, which are essential for the selective manipulation of steroid hydroxyl functions during complex multi-step syntheses. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel steroid-based therapeutics, hormone analogs, and advanced chemical probes.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel steroid drugs and hormone receptor modulators.
• Organic Synthesis Reagent: Used as a specialized silylating agent for the protection of sterically hindered hydroxyl groups in complex molecule construction.
• Research & Development: Serves as a precise chemical tool in academic and industrial R&D for studying steroid metabolism and structure-activity relationships (SAR).
• Process Chemistry: Employed in the development and scale-up of synthetic routes for active pharmaceutical ingredients (APIs) with steroidal backbones.
• Reference Standard: Can be used as a high-purity analytical standard for quality control and method development in steroid analysis.

Basic Information

Product Name	[(17-Methyl-5α-Androstane-3β,17β-Diyl)Bis(Oxy)]Bis(Trimethylsilane)
CAS No.	39780-71-7
Molecular Formula	C26H50O2Si2
Molecular Weight	450.86 g/mol
Synonyms	3β,17β-Bis(trimethylsilyloxy)-17-methyl-5α-androstane; 17-Methyl-5α-androstane-3β,17β-diol bis(trimethylsilyl) ether; Androstane-3β,17β-diol, 17-methyl-, bis(trimethylsilyl) ether; 5α-Androstane-3β,17β-diol, 17-methyl-, bis(trimethylsilyl) ether; 17-Methylandrostane-3β,17β-diol bis(TMS ether); TMS ether of 17-methyl-5α-androstane-3β,17β-diol
EINECS	Contact for details

Quality Control

Our [(17-Methyl-5α-Androstane-3β,17β-Diyl)Bis(Oxy)]Bis(Trimethylsilane) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can compromise product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.