Description

(E)-4-(Diethoxy-Phosphoryl)-3-Methyl-But-2-Enoic Acid Ethyl Ester is a high-purity, versatile organophosphorus intermediate essential for advanced chemical synthesis. This compound matters because it serves as a critical building block for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications such as Horner-Wadsworth-Emmons (HWE) olefination reactions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs) via olefination chemistry.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators requiring specific alkene geometries.
• Fine Chemical Manufacturing: Serves as a specialized reagent for the preparation of flavors, fragrances, and other high-value specialty chemicals.
• Material Science Research: Employed in the development of novel polymers and functional materials with tailored properties.
• Academic & Industrial R&D: A valuable tool for synthetic organic chemists exploring new carbon-carbon bond forming methodologies.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for commercial production.

Basic Information

Product Name	(E)-4-(Diethoxy-Phosphoryl)-3-Methyl-But-2-Enoic Acid Ethyl Ester
CAS No.	39760-56-0
Molecular Formula	C11H21O5P
Molecular Weight	264.26 g/mol
Synonyms	Ethyl (E)-4-(Diethoxyphosphoryl)-3-methylbut-2-enoate; (E)-Ethyl 4-(Diethoxyphosphoryl)-3-methyl-2-butenoate; 3-Methyl-2-butenoic acid, 4-(diethoxyphosphinyl)-, ethyl ester, (E)-; Diethyl [(E)-1-(Ethoxycarbonyl)-2-methylprop-1-en-1-yl]phosphonate; (E)-4-(Diethoxyphosphoryl)-3-methylbut-2-enoic acid ethyl ester; HWE Reagent derivative; Phosphonate olefination reagent
EINECS	Contact for details

Quality Control

Our (E)-4-(Diethoxy-Phosphoryl)-3-Methyl-But-2-Enoic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and isomeric integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
(E)-Isomer Content (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.