Description

2,5-Difluorophenyl Isocyanate is a versatile aromatic isocyanate monomer characterized by its reactive isocyanate group and fluorine-substituted phenyl ring. This compound is a critical building block in the synthesis of advanced polymers and fine chemicals, where its fluorine atoms impart enhanced chemical stability, lipophilicity, and metabolic resistance to the final products. It is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials industries for constructing ureas, carbamates, and other high-value heterocycles.

Application

• Pharmaceutical Intermediates: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used to manufacture advanced herbicides, fungicides, and insecticides, where the difluorophenyl moiety improves biological activity and environmental persistence.
• Polymer & Resin Modification: Serves as a cross-linking agent or chain extender in polyurethane and polyurea systems, enhancing thermal and chemical resistance.
• Liquid Crystal & OLED Materials: Building block for electron-transport materials and alignment layers in display technologies.
• Dye & Pigment Manufacturing: Intermediate for producing high-performance, light-fast organic pigments and dyes.
• Chemical Research & Development: Valuable reagent in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	2,5-Difluorophenyl Isocyanate
CAS No.	39718-32-6
Molecular Formula	C7H3F2NO
Molecular Weight	155.10 g/mol
Synonyms	2,5-Difluorophenyl isocyanate; 1,4-Difluoro-2-isocyanatobenzene; Isocyanic Acid, 2,5-Difluorophenyl Ester; 2,5-Difluorobenzene Isocyanate; 2,5-Difluoro Phenyl Isocyanate; 2,5-DFPI; 2,5-F2-PhNCO
EINECS	Contact for details

Quality Control

Our 2,5-Difluorophenyl Isocyanate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Keep away from heat, open flames, and sources of ignition. Isolate from amines, alcohols, water, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	~1.35 g/cm³
Boiling Point	~85-87°C at 10 mmHg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.