Description

Alpha,α-Dimethyl-3,5-Dimethoxybenzyloxycarbonyl-L-Proline is a specialized, optically active amino acid derivative used as a critical building block in advanced organic synthesis. Its primary value lies in its role as a protected form of L-proline, enabling precise control over stereochemistry in the construction of complex peptide and peptidomimetic structures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic agents, including protease inhibitors and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid to prevent racemization.
• Protease Inhibitor Development: Serves as a core structural component in the research and production of inhibitors targeting specific enzymes.
• Bioconjugation & Linker Chemistry: Employed in the design of drug-linker systems for antibody-drug conjugates (ADCs) and other targeted therapies.
• Chemical Biology Research: Utilized as a tool compound for studying protein-protein interactions and enzyme mechanisms.
• Asymmetric Catalysis: Can function as a precursor for chiral ligands or organocatalysts in stereoselective transformations.

Basic Information

Item	Details
Product Name	Alpha,α-Dimethyl-3,5-Dimethoxybenzyloxycarbonyl-L-Proline
CAS No.	39508-08-2
Molecular Formula	C₁₈H₂₅NO₆
Molecular Weight	351.40 g/mol
Synonyms	Ddz-L-Proline; (S)-1-[(3,5-Dimethoxyphenyl)dimethylcarbamoyl]pyrrolidine-2-carboxylic Acid; N-[(3,5-Dimethoxyphenyl)dimethylcarbamoyl]-L-proline; N-Ddz-L-Proline; 2-Pyrrolidinecarboxylic acid, 1-[[(3,5-dimethoxyphenyl)dimethylcarbamoyl]methyl]-, (S)-; L-Proline, N-[(3,5-dimethoxyphenyl)dimethylcarbamoyl]-; DDZ-Pro-OH; α,α-Dimethyl-3,5-dimethoxybenzyloxycarbonyl-L-proline
EINECS	Contact for details

Quality Control

Our Alpha,α-Dimethyl-3,5-Dimethoxybenzyloxycarbonyl-L-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.