Description

Diethyl 2-(Cyclopropylmethylene)Malonate is a high-purity, versatile malonate ester derivative characterized by its reactive cyclopropylmethylene moiety. This compound serves as a critical advanced pharmaceutical intermediate and a valuable building block in organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of cyclopropane-containing drug candidates, including potential antiviral and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Building block for creating novel pesticides and herbicides with enhanced activity and selectivity, leveraging the strained cyclopropane ring.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, fragrances, and advanced materials requiring specific cyclopropane motifs.
• Organic Synthesis Reagent: Serves as a Michael acceptor or a diester component in cyclization and annulation reactions (e.g., in the synthesis of carbocycles and heterocycles).
• Research & Development: Essential tool compound in academic and industrial R&D labs for methodology development and exploring new chemical spaces.
• Chemical Library Building: Employed in combinatorial chemistry and parallel synthesis to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	Diethyl 2-(Cyclopropylmethylene)Malonate
CAS No.	39000-53-8
Molecular Formula	C11H16O4
Molecular Weight	212.24 g/mol
Synonyms	Diethyl (cyclopropylmethylene)malonate; (Cyclopropylmethylene)malonic Acid Diethyl Ester; Propanedioic acid, 2-(cyclopropylmethylene)-, diethyl ester; Diethyl (cyclopropylidene)malonate; Malonic acid, (cyclopropylmethylene)-, diethyl ester; Diethyl cyclopropylidenemalonate; 2-(Cyclopropylmethylene)malonic acid diethyl ester
EINECS	Contact for details

Quality Control

Our Diethyl 2-(Cyclopropylmethylene)Malonate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for use as a pharmaceutical intermediate. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.