Description

1,2,3-Triacetyl-5-Deoxy-D-Ribose is a key protected sugar intermediate, specifically a fully acetylated derivative of deoxyribose. This compound is critical for synthetic chemists as it provides a stable, non-reactive scaffold for the controlled construction of nucleoside analogs and other complex carbohydrate-based molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral agents, anticancer drugs, and novel oligonucleotide therapeutics.

Application

• Nucleoside & Nucleotide Synthesis: Serves as a crucial building block for the preparation of modified nucleosides used in antiviral and anticancer research.
• Pharmaceutical Intermediates: Acts as a protected precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting various diseases.
• Oligonucleotide Chemistry: Used in the development of antisense oligonucleotides and siRNA constructs where a modified sugar backbone is required.
• Carbohydrate Chemistry Research: Provides a versatile starting material for academic and industrial research into novel glycosylation methods and carbohydrate-based polymers.
• Bioconjugation: The acetyl groups can be selectively deprotected to allow for site-specific conjugation with other biomolecules or labels.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for complex molecular targets in Good Manufacturing Practice (GMP) environments.

Basic Information

Product Name	1,2,3-Triacetyl-5-Deoxy-D-Ribose
CAS No.	38996-31-5
Molecular Formula	C11H16O7
Molecular Weight	260.24 g/mol
Synonyms	5-Deoxy-1,2,3-tri-O-acetyl-D-ribofuranose; 5-Deoxy-D-ribose 1,2,3-triacetate; 1,2,3-Tri-O-acetyl-5-deoxy-D-ribofuranose; 5-Deoxy-1,2,3-tri-O-acetyl-ribofuranose; D-Ribose, 5-deoxy-, 1,2,3-triacetate
EINECS	Contact for details

Quality Control

Our 1,2,3-Triacetyl-5-Deoxy-D-Ribose is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with key parameters including assay (HPLC), chiral purity, and residual solvent levels. Our quality commitment supports applications in research and cGMP-compliant pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.