Description

3-Pyridinecarboxylic Acid, 5-(1,2,3,4,5,6-Hexahydroazepino[4,5-B]Indol-5-Yl)-, Methyl Ester, (-)- is a complex, chiral heterocyclic compound that serves as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its sophisticated fused-ring structure, which makes it a key building block for the development of novel pharmacologically active molecules. This high-purity intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and novel therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for discovering new bioactive compounds.
• CNS Drug Development: Serves as a core scaffold for molecules targeting neurological pathways, given its indole-azepine-pyridine architecture.
• Oncology Research: Employed in the synthesis of potential kinase inhibitors or other targeted cancer therapies.
• Asymmetric Synthesis: Utilized as a chiral building block to introduce stereochemical complexity into target molecules.
• Process Chemistry & Scale-Up: Supports route development and optimization from milligram to kilogram scale for clinical trial material production.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	3-Pyridinecarboxylic Acid, 5-(1,2,3,4,5,6-Hexahydroazepino[4,5-B]Indol-5-Yl)-, Methyl Ester, (-)-
CAS No.	38940-72-6
Molecular Formula	C20H21N3O2
Molecular Weight	335.40 g/mol
Synonyms	(-)-5-(1,2,3,4,5,6-Hexahydroazepino[4,5-b]indol-5-yl)nicotinic acid methyl ester; Methyl 5-(1,2,3,4,5,6-hexahydroazepino[4,5-b]indol-5-yl)nicotinate; (S)-5-(1,2,3,4,5,6-Hexahydroazepino[4,5-b]indol-5-yl)nicotinic acid methyl ester; L-689,560 (common research code); Azepinoindole-pyridine derivative; Chiral nicotinate ester intermediate; 5-(Hexahydroazepino[4,5-b]indol-5-yl)-3-pyridinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 3-Pyridinecarboxylic Acid, 5-(1,2,3,4,5,6-Hexahydroazepino[4,5-B]Indol-5-Yl)-, Methyl Ester, (-)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles are provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storage under inert atmosphere (e.g., nitrogen or argon) to prevent potential oxidation. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.