Description

1,3,4,6-Tetra-o-Acetyl-2-Deoxy-2-Fluoro-D-Glucopyranose is a key fluorinated carbohydrate intermediate, specifically a protected fluorosugar derivative. Its core value lies in its role as a versatile building block for the synthesis of fluorinated nucleosides and other biologically active molecules. This compound is essential for research and development in the pharmaceutical and biotechnology sectors, particularly for antiviral and anticancer drug discovery programs. The CAS number for this material is 38711-38-5.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated nucleoside analogs used as antiviral (e.g., anti-HIV, anti-hepatitis) and anticancer agents.
• Probe Development: Used in medicinal chemistry to create molecular probes for studying enzyme mechanisms and carbohydrate metabolism, leveraging fluorine as a spectroscopic label.
• Glycoscience Research: Serves as a fundamental building block in synthetic carbohydrate chemistry for constructing complex, fluorinated oligosaccharides and glycoconjugates.
• PET Tracer Synthesis: Potential use as a starting material for developing positron emission tomography (PET) imaging agents, where fluorine-18 can be introduced or the structure serves as a precursor.
• Chemical Biology: Enables the study of glycosylation processes and the development of glycosidase inhibitors by incorporating a stable fluorine atom at the 2-position.

Basic Information

Product Name	1,3,4,6-Tetra-o-Acetyl-2-Deoxy-2-Fluoro-D-Glucopyranose
CAS No.	38711-38-5
Molecular Formula	C₁₄H₁₉FO₉
Molecular Weight	350.29 g/mol
Synonyms	2-Deoxy-2-fluoro-1,3,4,6-tetra-O-acetyl-α/β-D-glucopyranose; 2-Fluoro-2-deoxy-1,3,4,6-tetra-O-acetyl-D-glucopyranose; 1,3,4,6-Tetra-O-acetyl-2-deoxy-2-fluoro-D-glucose; Tetraacetyl-2-fluoro-2-deoxy-D-glucose; 2-Fluoro-1,3,4,6-tetra-O-acetyl-2-deoxy-D-glucopyranose; 2-Fluoro-2-deoxy-D-glucose tetraacetate; FDG Tetraacetate (precursor)
EINECS	Contact for details

Quality Control

Our 1,3,4,6-Tetra-o-Acetyl-2-Deoxy-2-Fluoro-D-Glucopyranose is manufactured under strict quality systems suitable for research and pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to ensure traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.