Description

17-Epi-Norethindrone CAS NO 38673-36-8 is a high-purity steroid derivative and an important isomer of the well-known progestin, norethindrone. This compound is a critical reference standard and a key synthetic intermediate in the research and development of novel pharmaceutical agents. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and fine chemical manufacturers engaged in the synthesis of steroid-based therapeutics and diagnostic tools.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis (HPLC, GC-MS) of norethindrone and related compounds in drug substances and finished products.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a crucial building block in the multi-step synthesis of advanced steroid-based pharmaceuticals.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research to understand the behavior of progestin drugs in biological systems.
• Biochemical Research: Used as a tool compound to study steroid hormone receptor interactions and activity in endocrinology research.
• Impurity Profiling: Essential for identifying and quantifying isomeric impurities in norethindrone API batches to ensure compliance with pharmacopeial standards (e.g., USP, EP).
• Custom Synthesis: A starting material for the preparation of specialized steroid derivatives for investigative or diagnostic purposes.

Basic Information

Product Name	17-Epi-Norethindrone
CAS No.	38673-36-8
Molecular Formula	C₂₀H₂₆O₂
Molecular Weight	298.42 g/mol
Synonyms	17α-Ethynyl-17β-hydroxy-19-norandrost-4-en-3-one; 17-Epinorethindrone; 17-Isonorethindrone; 17α-Norethindrone; 19-Nor-17α-pregn-4-en-20-yn-3-one, 17β-hydroxy-; (17α)-17-Hydroxy-19-norpregn-4-en-20-yn-3-one; 17-Epi-Norethisterone
EINECS	Contact for details

Quality Control

Our 17-Epi-Norethindrone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all test results against our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.