Description

Ampligen CAS NO 38640-92-5 is a mismatched double-stranded RNA (dsRNA) polymer, specifically a complex of poly(I) and poly(C12U). This compound is of significant interest as a selective toll-like receptor 3 (TLR3) agonist and a potent inducer of interferon production. It is primarily utilized in advanced pharmaceutical research and development, particularly in the fields of immunology, virology, and oncology. Its unique mechanism of action makes it a critical reagent for studying antiviral responses and immune modulation.

Application

• Immunological research as a TLR3 agonist to study innate immune signaling pathways.
• Virology studies for investigating antiviral responses and interferon-mediated defense mechanisms.
• Preclinical development of oncology therapeutics, exploring its potential as an immunomodulatory agent.
• Biochemical research to understand the structure and function of double-stranded RNA polymers and their interactions.
• Development of vaccine adjuvants due to its ability to stimulate a robust immune response.
• Cell culture studies to induce an interferon-rich environment for specific experimental models.

Basic Information

Product Name	Ampligen
CAS No.	38640-92-5
Molecular Formula	(C10H13N4O7P)n•(C39H49N15O22P3)m
Molecular Weight	High molecular weight polymer
Synonyms	Poly(I):Poly(C12U); Poly I:Poly C12U; Mismatched Double-Stranded RNA; rIn•r(C12U)n; Ampligen® (tradename); Atragen; Poly I:C12U; TLR3 Agonist
EINECS	Contact for details

Quality Control

Our Ampligen is produced under stringent quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity. We adhere to high standards suitable for pharmaceutical research, with testing protocols designed to confirm the structural integrity and functional performance of this critical biological polymer.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent absorption of atmospheric moisture. For short-term use, aliquots may be stored at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (IR / HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 95% (Polymeric content)
Endotoxin Level (LAL)	< 10 EU/mg
Biological Activity (Cell-based assay)	Conforms to reference (TLR3 activation)
Solubility	Soluble in sterile water or suitable buffer
Residual Moisture (KF)	< 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.