Description

17α-[(Trimethylsilyl)Oxy]-19-Norpregn-5(10)-En-20-Yn-3-One CAS NO 38631-87-7 is a high-purity, advanced steroid intermediate featuring a unique norpregnane backbone modified with a trimethylsilyloxy (TMS) protecting group and an ethynyl moiety. This compound matters as a critical building block in the synthesis of complex pharmaceutical actives, offering precise control over stereochemistry and functional group manipulation. It is primarily needed by research institutions and pharmaceutical manufacturers developing novel therapeutic agents, particularly in the fields of endocrinology and oncology.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel steroid-based drugs and hormonal therapies.
• Research Chemical: Used in academic and industrial R&D for studying steroid receptor activity and metabolic pathways.
• Process Development: Serves as a reference standard and starting material for optimizing scalable API (Active Pharmaceutical Ingredient) manufacturing routes.
• Precursor for Modified Steroids: The TMS-protected hydroxy and ethynyl groups allow for further selective chemical transformations to create targeted analogs.

Basic Information

Product Name	17α-[(Trimethylsilyl)Oxy]-19-Norpregn-5(10)-En-20-Yn-3-One
CAS No.	38631-87-7
Molecular Formula	C25H38O2Si
Molecular Weight	398.66 g/mol
Synonyms	19-Nor-17α-[(trimethylsilyl)oxy]pregn-5(10)-en-20-yn-3-one; 17α-TMS-Oxy-19-norpregn-5(10)-en-20-yn-3-one; 17α-(Trimethylsiloxy)-19-nor-5(10)-pregnen-20-yn-3-one; 19-Norpregn-5(10)-ene-20-yne-3,17-diol, 17-(trimethylsilyl) ether; NSC 118982; Pregna-5(10),20-dien-3-one, 17-(trimethylsilyl)oxy)-19-nor-
EINECS	Contact for details

Quality Control

Our 17α-[(Trimethylsilyl)Oxy]-19-Norpregn-5(10)-En-20-Yn-3-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Any single unknown impurity	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.