Description

3H-Spiro[2-Benzofuran-1,4'-Piperidine] is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic molecular architecture. This compound is of significant commercial interest for its role as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within the central nervous system (CNS) and other specialized drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• CNS Drug Discovery: Used in the synthesis of potential therapeutics targeting neurological and psychiatric disorders, leveraging the piperidine moiety.
• Chemical Synthesis: Employed in organic synthesis for constructing complex spirocyclic and heterocyclic frameworks.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	3H-Spiro[2-Benzofuran-1,4'-Piperidine]
CAS No.	38309-60-3
Molecular Formula	C12H13NO
Molecular Weight	187.24 g/mol
Synonyms	3H-Spiro[2-benzofuran-1,4'-piperidine]; 1',3'-Dihydrospiro[2-benzofuran-1,4'-piperidine]; Spiro[2-benzofuran-1,4'-piperidine], 1',3'-dihydro-; 1',3'-Dihydrospiro[isobenzofuran-1,4'-piperidine]; 38309-60-3; Spiro[isobenzofuran-1(3H),4'-piperidine]; Spiro[benzofuran-1(3H),4'-piperidine]
EINECS	Contact for details

Quality Control

Our 3H-Spiro[2-Benzofuran-1,4'-Piperidine] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment and can support development projects requiring compliance with cGMP or other stringent regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.