Description

Bicyclo[3.1.0]Hexane-6-Carboxylic Acid, Methyl Ester, (1Alpha,5Alpha,6Alpha)- (9Ci) is a high-purity, stereochemically defined bicyclic ester compound that serves as a critical chiral building block and synthetic intermediate. Its unique strained bicyclo[3.1.0]hexane scaffold is of significant value for constructing complex molecular architectures with precise three-dimensional control. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications requiring rigid, functionalized core structures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the construction of advanced pesticide and herbicide molecules, where its bicyclic framework can impart favorable biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce high enantioselectivity.
• Material Science Research: Employed as a monomer or cross-linking agent in the development of specialty polymers with unique thermal or mechanical properties.
• Chemical Biology Probe: Useful for creating molecular probes to study enzyme mechanisms or protein-ligand interactions due to its constrained geometry.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis, including cycloaddition and ring-opening reactions.

Basic Information

Item	Details
Product Name	Bicyclo[3.1.0]Hexane-6-Carboxylic Acid, Methyl Ester, (1Alpha,5Alpha,6Alpha)- (9Ci)
CAS No.	38284-36-5
Molecular Formula	C9H12O2
Molecular Weight	152.19 g/mol
Synonyms	(1α,5α,6α)-Bicyclo[3.1.0]hexane-6-carboxylic acid methyl ester; Methyl (1α,5α,6α)-bicyclo[3.1.0]hexane-6-carboxylate; endo-Methyl bicyclo[3.1.0]hexane-6-carboxylate; (1R,5S,6R)-Bicyclo[3.1.0]hexane-6-carboxylic acid methyl ester; Methyl 6-carboxybicyclo[3.1.0]hexane-6-carboxylate (stereospecific); Bicyclo[3.1.0]hexane-6-methyl carboxylate; 38284-36-5
EINECS	Contact for details

Quality Control

Our production of Bicyclo[3.1.0]Hexane-6-Carboxylic Acid, Methyl Ester adheres to stringent quality protocols suitable for research and process development applications. Each batch is characterized using advanced analytical techniques including chiral HPLC, GC-MS, and NMR to ensure high chemical and isomeric purity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.