Description

Prolyl-m-(Bis(Chloroethyl)Amino)Phenylalanyl-Norvaline Ethyle Ester Hydrochloride is a specialized synthetic peptide derivative with a complex molecular architecture. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its potential as a targeted therapeutic agent or a key synthetic intermediate. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel drug candidates, especially in the fields of oncology and targeted therapies. The precise structure allows for specific biological interactions, making it a valuable tool for medicinal chemists.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex peptide-based drug candidates.
• Oncology Research: Investigated for its potential as a targeted cytostatic or cytotoxic agent due to the presence of the nitrogen mustard moiety (bis(chloroethyl)amino group).
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of peptide therapeutics.
• Bioconjugation: Acts as a functionalized peptide linker for attaching cytotoxic payloads to antibodies or other targeting molecules in Antibody-Drug Conjugate (ADC) development.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand specific protease interactions.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Prolyl-m-(Bis(Chloroethyl)Amino)Phenylalanyl-Norvaline Ethyle Ester Hydrochloride
CAS No.	38232-20-1
Molecular Formula	C31H50Cl3N5O5 • HCl
Molecular Weight	691.1 g/mol (for free base C31H50Cl3N5O5)
Synonyms	m-[N,N-Bis(2-chloroethyl)amino]phenylalanylprolylnorvaline Ethyl Ester Hydrochloride; L-Phenylalanine, N-[N-[N-[1-(3-[bis(2-chloroethyl)amino]phenyl)-1-oxo-3-phenyl-2-propanyl]-L-prolyl]-L-norvalyl]-, ethyl ester, hydrochloride; Pro-Phe-m-(Bis-Chloroethylamino)-Norval-OEt • HCl; Peptide Chlorambucil Derivative; Nitrogen Mustard Peptide Ester Hydrochloride; 38232-20-1; CAS 38232-20-1
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical intermediates. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for each lot are available upon request. We adhere to strict internal quality management protocols to support our clients' needs for reliable and traceable materials in critical development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0% (Total peak area)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.