Description

D-Proline, 1,5-Dimethyl-, Methyl Ester, (5S)-Rel- (9Ci) is a high-purity, non-natural proline derivative characterized by its specific stereochemistry and ester functionalization. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecules with precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptidomimetics, and other fine chemicals where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for protease inhibitors and other peptide-based drugs.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce high enantioselectivity.
• Peptidomimetics Research: Used to synthesize modified peptide structures that mimic natural peptides but with enhanced stability or biological activity.
• Agrochemical Development: Serves as a building block for creating chiral active ingredients with specific biological functions.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and for scaling up novel synthetic routes.
• Fine Chemical Production: Used in the custom synthesis of specialty chemicals for various high-value industrial applications.

Basic Information

Product Name	D-Proline, 1,5-Dimethyl-, Methyl Ester, (5S)-Rel- (9Ci)
CAS No.	38228-18-1
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	(5S)-rel-1,5-Dimethyl-L-proline methyl ester; Methyl (5S)-rel-1,5-dimethyl-L-prolinate; Methyl 1,5-dimethyl-D-prolinate; D-1,5-Dimethylproline methyl ester; (2S,5S)-1,5-Dimethylpyrrolidine-2-carboxylic acid methyl ester (relative configuration); Proline, 1,5-dimethyl-, methyl ester, (5S)-rel-; 38228-18-1
EINECS	Contact for details

Quality Control

Our D-Proline, 1,5-Dimethyl-, Methyl Ester, (5S)-Rel- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC and structural confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.