Description

(+)-6,6'-Dimethoxy-2,2'-Biphenyldicarboxylic Acid Dimethyl Ester is a high-purity, chiral biphenyl derivative that serves as a critical advanced intermediate in sophisticated organic synthesis. Its enantiomerically pure structure makes it an invaluable building block for constructing complex molecules with specific stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating active pharmaceutical ingredients (APIs), chiral ligands, and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, especially for central nervous system (CNS) and cardiovascular targets.
• Chiral Ligand Synthesis: Used to develop enantioselective catalysts and ligands for asymmetric synthesis in fine chemical production.
• Agrochemical Research: Employed in the creation of advanced, stereospecific pesticides and herbicides.
• Material Science: Acts as a monomer or building block for chiral polymers and liquid crystalline materials.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry and catalysis at universities and corporate research labs.

Basic Information

Product Name	(+)-6,6'-Dimethoxy-2,2'-Biphenyldicarboxylic Acid Dimethyl Ester
CAS No.	38197-42-1
Molecular Formula	C₁₈H₁₈O₆
Molecular Weight	330.33 g/mol
Synonyms	(+)-Dimethyl 6,6'-dimethoxybiphenyl-2,2'-dicarboxylate; (R)-(+)-6,6'-Dimethoxy-2,2'-biphenyldicarboxylic Acid Dimethyl Ester; (R)-Dimethyl 2,2'-dimethoxy-6,6'-dicarboxylate-1,1'-biphenyl; Biphenyl-2,2'-dicarboxylic acid, 6,6'-dimethoxy-, dimethyl ester, (R)-; (+)-Dimethyl 2,2'-dimethoxy-6,6'-dicarboxybiphenyl; (R)-BINOL-DM derivative
EINECS	Contact for details

Quality Control

Our production of (+)-6,6'-Dimethoxy-2,2'-Biphenyldicarboxylic Acid Dimethyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and optical rotation measurement. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment, supporting compliance in cGMP-oriented applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and chiral integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Melting Point	Contact for details
Specific Rotation [α]	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.