Description

3-Bromo-1-(Trimethylsilyl)-1-Propyne is a versatile organosilicon building block featuring both a bromo and a terminal alkyne functional group. This bifunctional nature makes it a critical intermediate for constructing complex molecular architectures via cross-coupling and click chemistry reactions. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, reliable synthons for drug discovery and specialty polymer synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates via Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the production of advanced fungicides, herbicides, and plant growth regulators that require silicon-containing alkyne motifs.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialty silicon-acetylene polymers, dendrimers, and advanced resins with tailored thermal and mechanical properties.
• Organic Synthesis & Click Chemistry: An ideal substrate for Huisgen 1,3-dipolar cycloaddition (click chemistry) to create triazole-linked compounds for bioconjugation and ligand discovery.
• Ligand & Catalyst Development: Employed in the preparation of novel phosphine or N-heterocyclic carbene (NHC) ligands where the trimethylsilyl-protected alkyne acts as a versatile handle.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D labs exploring new synthetic methodologies and organometallic complexes.

Basic Information

Product Name	3-Bromo-1-(Trimethylsilyl)-1-Propyne
CAS No.	38002-45-8
Molecular Formula	C6H11BrSi
Molecular Weight	191.14 g/mol
Synonyms	1-Trimethylsilyl-3-bromopropyne; 3-Bromo-1-(trimethylsilyl)propyne; 3-Bromoprop-1-yn-1-yltrimethylsilane; (3-Bromoprop-1-yn-1-yl)trimethylsilane; Trimethyl(3-bromoprop-1-yn-1-yl)silane; TMS-Propargyl Bromide (common name); Bromo(trimethylsilyl)propyne
EINECS	Contact for details

Quality Control

Our 3-Bromo-1-(Trimethylsilyl)-1-Propyne is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; keep container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.