Description

2-Chloro-4-Trimethylsilanylethynyl-Pyrimidine is a high-value organosilicon building block featuring a reactive ethynyl group protected by a trimethylsilyl (TMS) moiety. This compound is critical for advanced organic synthesis, particularly in the construction of complex heterocyclic systems and functional materials. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as cross-coupling reactions and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly for constructing pyrimidine-based scaffolds via Sonogashira and other cross-coupling reactions.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate functionalized pyrimidine rings.
• Material Science Precursor: Serves as a monomer or building block for creating advanced polymers, liquid crystals, and organic electronic materials with tailored properties.
• Chemical Synthesis Reagent: Employed in academic and industrial R&D for the preparation of complex molecules, leveraging the protected alkyne for selective deprotection and further functionalization.
• Ligand and Catalyst Development: Used to synthesize novel ligands for metal catalysts or as a component in organometallic complexes.

Basic Information

Product Name	2-Chloro-4-Trimethylsilanylethynyl-Pyrimidine
CAS No.	37972-23-9
Molecular Formula	C9H11ClN2Si
Molecular Weight	210.74 g/mol
Synonyms	2-Chloro-4-((trimethylsilyl)ethynyl)pyrimidine; 4-((Trimethylsilyl)ethynyl)-2-chloropyrimidine; 2-Chloro-4-(trimethylsilylethynyl)pyrimidine; Pyrimidine, 2-chloro-4-[(trimethylsilyl)ethynyl]-; 2-Chloro-4-(2-trimethylsilylethynyl)pyrimidine; 37972-23-9; 2-Chloro-4-(trimethylsilylethinyl)pyrimidine
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Trimethylsilanylethynyl-Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.