Description

tert-Butyl (S)-(-)-2-Hydroxybutyrate is a high-purity chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a protected form of (S)-2-hydroxybutyric acid, offering enhanced stability and reactivity control for stereoselective transformations. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and complex natural products.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drugs, especially in cardiovascular and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Fine Chemical Production: Serves as a versatile building block for fragrances, flavors, and other specialty chemicals requiring high optical purity.
• Asymmetric Catalysis Research: Employed as a standard or ligand precursor in academic and industrial research to develop new catalytic methodologies.
• Peptide Mimetics: Utilized in the construction of non-natural amino acid derivatives and peptidomimetics for drug discovery.
• Polymer Chemistry: Can act as a monomer or initiator for synthesizing polymers with controlled tacticity and functional groups.

Basic Information

Product Name	tert-Butyl (S)-(-)-2-Hydroxybutyrate
CAS No.	37787-90-9
Molecular Formula	C8H16O3
Molecular Weight	160.21 g/mol
Synonyms	(S)-(-)-2-Hydroxybutyric Acid tert-Butyl Ester; (S)-tert-Butyl 2-Hydroxybutanoate; (S)-2-Hydroxybutanoic Acid 1,1-Dimethylethyl Ester; tert-Butyl (S)-2-Hydroxybutyrate; (S)-(-)-2-Hydroxybutyric Acid t-Butyl Ester; (S)-HOBu-OtBu; L-2-Hydroxybutyric Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (S)-(-)-2-Hydroxybutyrate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please inquire.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]	-10.0° to -12.0° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.