Description

5-Oxo-2-Azabicyclo[2.2.2]Octane-2-Carboxylic Acid Ethyl Ester is a high-value, bicyclic lactam derivative serving as a critical chiral building block in advanced organic synthesis. Its rigid, bridged structure makes it an essential intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for developing novel active pharmaceutical ingredients (APIs) and other high-performance specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) and antiviral applications.
• Asymmetric Synthesis: Utilized as a versatile scaffold for constructing enantiomerically pure compounds via its reactive lactam and ester functionalities.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in stereoselective transformations.
• Peptidomimetics Research: Its constrained bicyclic structure is valuable for designing and synthesizing peptide mimics with enhanced metabolic stability.
• Agrochemical Synthesis: Employed in the development of advanced, high-specificity crop protection agents and pesticides.
• Material Science Precursor: Used in the synthesis of specialty polymers and advanced materials requiring specific molecular geometries.

Basic Information

Product Name	5-Oxo-2-Azabicyclo[2.2.2]Octane-2-Carboxylic Acid Ethyl Ester
CAS No.	37778-51-1
Molecular Formula	C10H15NO3
Molecular Weight	197.23 g/mol
Synonyms	Ethyl 5-oxo-2-azabicyclo[2.2.2]octane-2-carboxylate; 2-Azabicyclo[2.2.2]octane-2-carboxylic acid, 5-oxo-, ethyl ester; 2-Ethoxycarbonyl-2-azabicyclo[2.2.2]octan-5-one; 5-Oxo-2-azabicyclo[2.2.2]octane-2-carboxylic acid ethyl ester; 2-Azabicyclo[2.2.2]octan-5-one, 2-(ethoxycarbonyl)-; Ethyl 2-azabicyclo[2.2.2]octane-2-carboxylate 5-oxide (related form).
EINECS	Contact for details

Quality Control

Our 5-Oxo-2-Azabicyclo[2.2.2]Octane-2-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and chiral integrity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain product stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.