Description

(R)-1-Carboxy-3-Methylbutyl 5-Oxo-L-Prolinate is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound is valued for its role as a key building block in the production of complex active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and metabolic diseases. It is primarily required by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development and scale-up of enantiomerically pure therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of angiotensin-converting enzyme (ACE) inhibitors and other cardiovascular drugs.
• API Manufacturing: Used in the production scale-up of enantiomerically pure active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Serves as a building block in the research and development of novel peptidomimetics and protease inhibitors.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric synthesis routes due to its defined stereochemistry.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Bioconjugation Chemistry: Potential use in the synthesis of targeted drug conjugates and prodrugs.

Basic Information

Product Name	(R)-1-Carboxy-3-Methylbutyl 5-Oxo-L-Prolinate
CAS No.	37755-50-3
Molecular Formula	C12H19NO5
Molecular Weight	257.28 g/mol
Synonyms	(R)-1-Carboxy-3-methylbutyl 5-oxo-L-prolinate; L-Proline, 5-oxo-, (R)-1-carboxy-3-methylbutyl ester; (R)-1-Carboxy-3-methylbutyl 5-oxopyrrolidine-2-carboxylate; (R)-1-(Methoxycarbonyl)-3-methylbutyl 5-oxo-L-prolinate; (R)-1-Carboxy-3-methylbutyl 5-oxo-L-proline; (R)-1-Carboxy-3-methylbutyl 5-oxoproline; (R)-1-Carboxy-3-methylbutyl 5-oxo-L-prolinic acid ester; (R)-1-Carboxy-3-methylbutyl 5-oxo-L-prolinic ester
EINECS	Contact for details

Quality Control

Our (R)-1-Carboxy-3-Methylbutyl 5-Oxo-L-Prolinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee traceability and batch-to-batch consistency for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccant use and a nitrogen atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.