Description

(R)-1-Phosphono-Benzylamine is a chiral, non-racemic organophosphorus compound featuring both a phosphonic acid and a benzylamine functional group. This unique bifunctional structure makes it a valuable chiral building block and ligand in asymmetric synthesis and pharmaceutical research. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the development of novel active ingredients and catalytic systems.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological or metabolic diseases.
• Asymmetric Catalysis Ligand: Serves as a precursor for chiral phosphine-amine (P,N) or other hybrid ligands used in transition metal-catalyzed asymmetric reactions, such as hydrogenation or cross-coupling.
• Agrochemical Research: Employed in the synthesis of chiral herbicides, fungicides, or plant growth regulators where stereochemistry impacts biological activity.
• Bioconjugation & Probe Development: The phosphonic acid group allows for stable chelation or surface modification, useful in creating biochemical probes or diagnostic agents.
• Material Science: Potential monomer or additive for creating functional polymers with specific metal-binding or chiral properties.
• Academic & Process R&D: Used in universities and corporate R&D labs for methodological studies in organic synthesis and catalysis.

Basic Information

Product Name	(R)-1-Phosphono-Benzylamine
CAS No.	37714-05-9
Molecular Formula	C7H10NO3P
Molecular Weight	187.13 g/mol
Synonyms	(R)-α-Aminobenzylphosphonic Acid; (R)-1-Amino-1-phenylmethylphosphonic Acid; (R)-1-Amino-1-phenylethylphosphonic Acid (common misnomer); (R)-Benzylaminophosphonic Acid; (R)-Phenylglycine Phosphonic Acid Analog; (R)-AMPB; (R)-Phosphonophenylglycine; D-1-Phosphono-Benzylamine
EINECS	Contact for details

Quality Control

Our (R)-1-Phosphono-Benzylamine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and specific impurity profiles. We support cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent decomposition. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Enantiomeric Excess (Chiral HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.