Description

Hexadecyl 5-Oxo-L-Prolinate is a high-purity, lipophilic derivative of L-pyroglutamic acid, designed to enhance the bioavailability and skin penetration of active ingredients. This compound matters for formulators seeking to improve the stability and delivery efficacy of functional molecules in challenging matrices. It is primarily needed by manufacturers in the personal care, cosmetic, and pharmaceutical industries for advanced dermal delivery systems and specialty chemical synthesis.

Application

• Cosmetic & Personal Care Actives: As a key penetration enhancer and stabilizer in anti-aging serums, moisturizers, and skin repair formulations.
• Pharmaceutical Intermediates: Used in the synthesis of prodrugs and active pharmaceutical ingredients (APIs) requiring improved lipid solubility.
• Advanced Delivery Systems: A functional component in liposomes, nanoemulsions, and other colloidal carriers for targeted delivery.
• Hair Care Products: Incorporated into conditioners and treatments to improve the deposition and efficacy of proteins and vitamins.
• Biochemical Research: Serves as a substrate or building block in enzymatic studies and metabolic pathway research.
• Specialty Surfactants & Emulsifiers: Acts as a mild, multifunctional co-emulsifier in high-end cosmetic creams and lotions.

Basic Information

Product Name	Hexadecyl 5-Oxo-L-Prolinate
CAS No.	37673-20-4
Molecular Formula	C21H39NO4
Molecular Weight	369.54 g/mol
Synonyms	1-Hexadecyl 5-oxo-L-prolinate; Cetyl 5-oxo-L-prolinate; L-Pyroglutamic acid cetyl ester; Cetyl L-pyroglutamate; Hexadecyl L-pyroglutamate; 5-Oxo-L-proline hexadecyl ester; (S)-1-(Hexadecyloxy)-5-oxopyrrolidine-2-carboxylate; PCA Cetyl Ester
EINECS	Contact for details

Quality Control

Our Hexadecyl 5-Oxo-L-Prolinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for assay and purity, to ensure it meets stringent specifications for cosmetic and pharmaceutical-grade intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white powder or waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.