Description

(R)-n-Boc-(4-Pyridyl)Alanine CAS NO 37535-58-3 is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine and a 4-pyridyl side chain. This compound is a critical chiral building block for the synthesis of complex bioactive molecules, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide mimetic development, medicinal chemistry, and the creation of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Peptidomimetics & Constrained Peptides: Used to incorporate a rigid, aromatic heterocycle into peptide backbones to enhance metabolic stability, bioavailability, and binding affinity.
• Medicinal Chemistry & SAR Studies: Essential for structure-activity relationship (SAR) explorations to optimize the potency and selectivity of lead compounds.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric synthesis and organocatalysis.
• Bioconjugation & Probe Synthesis: The Boc-protected amine allows for selective deprotection and conjugation, useful in creating fluorescent probes or affinity labels.
• Academic & Institutional Research: Employed in chemical biology and organic synthesis research to study enzyme inhibition and protein-protein interactions.

Basic Information

Item	Detail
Product Name	(R)-n-Boc-(4-Pyridyl)Alanine
CAS No.	37535-58-3
Molecular Formula	C13H18N2O4
Molecular Weight	266.30 g/mol
Synonyms	(R)-3-(4-Pyridyl)-2-((tert-butoxycarbonyl)amino)propanoic acid; (R)-2-((tert-Butoxycarbonyl)amino)-3-(4-pyridyl)propanoic acid; Boc-(R)-3-(4-Pyridyl)alanine; (R)-Boc-4-Pal-OH; (R)-N-Boc-4-pyridylalanine; tert-Butyl (R)-2-amino-3-(4-pyridyl)propanoate; (R)-N-(tert-Butoxycarbonyl)-3-(4-pyridinyl)alanine
EINECS	Contact for details

Quality Control

Every batch of (R)-n-Boc-(4-Pyridyl)Alanine is manufactured under strict quality management protocols. We guarantee high chiral purity and chemical consistency through advanced analytical techniques including HPLC, NMR, and optical rotation measurement. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with each shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.