Description

Cbz-D-Phenylalanine Methyl Ester is a protected amino acid derivative widely used as a key chiral building block in organic synthesis. This high-purity intermediate is essential for the production of complex peptides and active pharmaceutical ingredients (APIs) where stereochemical integrity is paramount. It is primarily utilized by research institutions, pharmaceutical development labs, and fine chemical manufacturers engaged in peptide synthesis and medicinal chemistry.

Application

• Peptide Synthesis: A crucial chiral intermediate for the solid-phase and solution-phase synthesis of custom peptides and peptide mimetics.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of protease inhibitors, renin inhibitors, and other therapeutic agents.
• Bioconjugation & Linker Chemistry: Used in the preparation of peptide-drug conjugates (PDCs) and other bioconjugates due to its orthogonal protecting group.
• Chemical Biology Research: Employed in the development of peptide-based probes, substrates, and inhibitors for studying enzyme function and biological pathways.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in the preparation of non-natural amino acids and other enantiomerically pure compounds.
• Fine Chemical Production: A valuable intermediate for manufacturers specializing in high-value, custom-synthesized organic molecules for various industrial applications.

Basic Information

Product Name	Cbz-D-Phenylalanine Methyl Ester
CAS No.	37440-07-6
Molecular Formula	C18H19NO4
Molecular Weight	313.35 g/mol
Synonyms	N-Carbobenzoxy-D-phenylalanine methyl ester; N-Cbz-D-Phe-OMe; (R)-Methyl 2-((((benzyloxy)carbonyl)amino)-3-phenylpropanoate; D-Phenylalanine, N-[(phenylmethoxy)carbonyl]-, methyl ester; Z-D-Phe-OMe; Benzyloxycarbonyl-D-phenylalanine methyl ester; Methyl N-carbobenzoxy-D-phenylalaninate
EINECS	Contact for details

Quality Control

Our Cbz-D-Phenylalanine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Melting Point	78°C - 82°C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.