Description

Maloprim is a synthetic antimalarial agent, specifically a combination drug containing pyrimethamine and dapsone. This compound is critical for the prophylaxis and treatment of malaria, particularly in regions with chloroquine-resistant strains of *Plasmodium falciparum*. It is primarily required by pharmaceutical manufacturers, research institutions, and public health organizations involved in developing and distributing antimalarial therapies.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in fixed-dose combination antimalarial tablets.
• Malaria Prophylaxis: Formulated for use in preventing malaria infections in travelers and populations in endemic areas.
• Malaria Treatment: Used in therapeutic regimens, often in combination with other agents, for treating acute malaria cases.
• Pharmacological Research: Serves as a reference standard and investigational compound in studies of antiparasitic mechanisms and drug resistance.
• Public Health Programs: Supplied for large-scale distribution in national and international malaria control initiatives.
• Formulation Development: Used in R&D for developing new dosage forms, such as dispersible tablets or pediatric formulations.

Basic Information

Product Name	Maloprim
CAS No.	37357-69-0
Molecular Formula	C29H32N6O2S
Molecular Weight	528.67 g/mol
Synonyms	Pyrimethamine-Dapsone Combination; Dapsone-Pyrimethamine; Dapson-Pyrimethamin; Malocide (historical brand); Maloprim (brand); Antimalarial Combination Drug; 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine - 4,4'-Sulfonylbisbenzenamine (1:1); Dapsone compound with pyrimethamine (1:1)
EINECS	Contact for details

Quality Control

Our Maloprim is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with comprehensive analysis of the pyrimethamine and dapsone components. Certificates of Analysis (COA) are provided, detailing identity, potency, and impurity profiles. We support compliance with relevant pharmacopeial standards (such as USP/BP) and cGMP guidelines for active pharmaceutical ingredients (APIs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (Pyrimethamine)	47.0% - 53.0%
Assay (Dapsone)	47.0% - 53.0%
Related Substances (HPLC)	NMT 2.0% total impurities
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.