Description

Sulfadoxine-Pyrimethamine CAS NO 37338-39-9 is a fixed-dose combination of two active pharmaceutical ingredients (APIs) used as an antimalarial agent. This combination is critical for its synergistic effect, targeting different stages of the malaria parasite's folate biosynthesis pathway to prevent and treat infections. It is primarily required by pharmaceutical manufacturers and global health organizations for the production of antimalarial medications, particularly for use in intermittent preventive therapy (IPT) and in regions with specific malaria resistance patterns.

Application

• Pharmaceutical Formulation: Primary use in the manufacture of fixed-dose combination tablets for the treatment and prevention of malaria.
• Intermittent Preventive Therapy (IPT): A key component in regimens for preventing malaria in pregnant women (IPTp) and infants (IPTi) in endemic regions.
• Combination Therapy: Used in specific antimalarial protocols to combat Plasmodium falciparum strains resistant to single-agent therapies.
• Veterinary Medicine: Potential application in the treatment of certain protozoal infections in animals.
• Reference Standard: Serves as a chemical reference standard in quality control laboratories for drug analysis and method validation.
• Research & Development: Utilized in pharmacological studies and the development of new therapeutic formulations targeting parasitic diseases.

Basic Information

Product Name	Sulfadoxine-Pyrimethamine
CAS No.	37338-39-9
Molecular Formula	C₁₂H₁₄N₄O₄S • C₁₂H₁₃ClN₄
Molecular Weight	500.94 g/mol (Combined)
Synonyms	Sulfadoxine and Pyrimethamine; SP; Fansidar® (Trade Name); Sulfadoxinum et Pyrimethaminum; Sulfadoxine/Pyrimethamine Combination; Sulphadoxine and Pyrimethamine; Antimalarial Combination API; Fixed-Dose Antifolate Combination
EINECS	Contact for details

Quality Control

Our Sulfadoxine-Pyrimethamine is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and ICH Q7 guidelines. Every batch undergoes comprehensive analytical testing including identification, assay, and impurity profiling to ensure high purity and consistent potency. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee full traceability and regulatory support for our clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Sulfadoxine Content	Specified ratio
Pyrimethamine Content	Specified ratio
Related Substances (HPLC)	Meets pharmacopoeial limits
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.