Description

Dithiothreitol Tetraacetate is a high-purity, acetylated derivative of dithiothreitol (DTT), designed for applications requiring a more stable and lipophilic reducing agent. This compound matters for researchers and manufacturers who need precise control over disulfide bond reduction in complex organic synthesis and biochemical processes. It is primarily needed by the pharmaceutical, biotechnology, and fine chemical industries for applications in peptide synthesis, protein chemistry, and as a specialized reagent in molecular biology.

Application

• Peptide Synthesis: Acts as a selective and stable reducing agent for the deprotection of cysteine residues during solid-phase peptide synthesis (SPPS).
• Protein Chemistry: Used for the controlled reduction of disulfide bonds in proteins and enzymes under mild conditions.
• Bioconjugation: Serves as a key reagent in the preparation of thiol-reactive probes and for introducing sulfhydryl groups into biomolecules.
• Molecular Biology: Employed in buffer systems for stabilizing sensitive enzymes and maintaining reducing environments in biochemical assays.
• Fine Chemical Intermediate: Utilized as a building block in the synthesis of more complex chiral molecules and pharmaceutical intermediates.
• Polymer Modification: Applied in the functionalization of polymers to introduce thiol groups for cross-linking or further chemical modification.

Basic Information

Product Name	Dithiothreitol Tetraacetate
CAS No.	37180-63-5
Molecular Formula	C14H22O8S2
Molecular Weight	382.45 g/mol
Synonyms	DTT Tetraacetate; meso-1,4-Dimercapto-2,3-butanediol Tetraacetate; (2R,3R)-1,4-Dimercaptobutane-2,3-diyl Diacetate; 1,4-Dimercapto-2,3-butanediol Tetraacetate; Tetraacetyl Dithiothreitol; DTT-TA; Dithiothreitol Tetra Acetate; (R,R)-Dithiothreitol Tetraacetate
EINECS	Contact for details

Quality Control

Our Dithiothreitol Tetraacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing purity, physical characteristics, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is moisture-sensitive; keep the container tightly sealed in a desiccated environment. For long-term storage, consider storing under an inert atmosphere to prevent oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	108°C - 112°C
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.