Description

(4S,5S)-2,2-Dimethyl-1,3-Dioxolane-4,5-Dicarboxylic Acid Dimethyl Ester is a high-value chiral building block and protected derivative of tartaric acid. This compound matters for its role in asymmetric synthesis, providing a rigid, stereodefined scaffold for constructing complex pharmaceutical intermediates and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing enantiomerically pure active ingredients.

Application

• Chiral Auxiliary and Ligand Precursor: Serves as a starting material for synthesizing chiral catalysts and ligands used in asymmetric hydrogenation and other stereoselective transformations.
• Pharmaceutical Intermediate: A key synthon in the production of antiviral drugs, protease inhibitors, and other therapeutics where specific stereochemistry is critical for biological activity.
• Agrochemical Synthesis: Used in the manufacture of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products requiring the (4S,5S) tartrate-derived stereocenter.
• Resolution Agent: Can be utilized in the chiral resolution of racemic mixtures of acids or amines.
• Polymer Chemistry: Acts as a monomer or co-monomer for creating polymers with specific chiral architectures or functional groups.

Basic Information

Item	Details
Product Name	(4S,5S)-2,2-Dimethyl-1,3-Dioxolane-4,5-Dicarboxylic Acid Dimethyl Ester
CAS No.	37031-30-4
Molecular Formula	C9H14O6
Molecular Weight	218.21 g/mol
Synonyms	(4S,5S)-(-)-2,2-Dimethyl-1,3-dioxolane-4,5-dicarboxylic acid dimethyl ester; (S,S)-(-)-Dimethyl 2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate; (4S,5S)-Dimethyl O,O'-isopropylidene-2,3-O-isopropylidene-L-tartrate; L-(+)-Dimethyl tartrate acetonide; (S,S)-Dimethyl tartrate acetonide; (-)-Dimethyl 2,3-O-isopropylidene-L-tartrate; (4S,5S)-DMT acetonide
EINECS	Contact for details

Quality Control

Our (4S,5S)-2,2-Dimethyl-1,3-Dioxolane-4,5-Dicarboxylic Acid Dimethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and enantiomeric purity, meeting the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The product is stable under these conditions but should be kept away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	78 - 82 °C
Specific Rotation [α]20/D	-18° to -22° (c=1 in CHCl3)
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.