Description

(4R,5R)-2,2-Dimethyl-1,3-Dioxolane-4,5-Dicarboxylic Acid Dimethyl Ester is a high-purity chiral building block and protected derivative of tartaric acid. This compound is valued for its role as a key intermediate in the stereoselective synthesis of complex molecules, particularly in the pharmaceutical and fine chemical industries. It is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), asymmetric catalysts, and advanced materials where precise stereochemistry is critical.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of antiviral drugs, protease inhibitors, and other stereochemically complex active pharmaceutical ingredients (APIs).
• Asymmetric Catalyst Ligand Precursor: Used in the preparation of chiral ligands for transition metal catalysis, enabling enantioselective reactions.
• Fine Chemical Synthesis: Serves as a protected form of tartaric acid for the production of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Industrial Research: A valuable reagent in methodological development for organic synthesis and stereochemistry studies.
• Material Science: Potential monomer or precursor for chiral polymers and advanced functional materials.

Basic Information

Product Name	(4R,5R)-2,2-Dimethyl-1,3-Dioxolane-4,5-Dicarboxylic Acid Dimethyl Ester
CAS No.	37031-29-1
Molecular Formula	C9H14O6
Molecular Weight	218.21 g/mol
Synonyms	Dimethyl (4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-dicarboxylate; (R,R)-(-)-2,3-O-Isopropylidene-D-tartaric Acid Dimethyl Ester; (-)-Dimethyl (R,R)-O-Isopropylidene Tartrate; (4R,5R)-(-)-2,2-Dimethyl-1,3-dioxolane-4,5-dicarboxylic Acid Dimethyl Ester; D-(-)-Dimethyl Tartrate Acetonide; (R,R)-Tartaric Acid Dimethyl Ester Acetonide; (R,R)-DIPT Acetonide; L-7704
EINECS	Contact for details

Quality Control

Our (4R,5R)-2,2-Dimethyl-1,3-Dioxolane-4,5-Dicarboxylic Acid Dimethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. The compound is stable under these conditions for extended periods.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	88 - 92 °C
Specific Rotation [α]20/D	-18.0° to -22.0° (c=1 in CHCl3)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.