Description

n-(Trimethylsilyl)-6-[(Trimethylsilyl)Oxy]-8-Quinolinamine is a specialized organosilicon derivative of 8-aminoquinoline, featuring dual trimethylsilyl protecting groups. This compound is valued for its role as a key synthetic intermediate and protecting group reagent in advanced organic synthesis, particularly for sensitive nitrogen and oxygen functionalities. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a protected precursor in the synthesis of novel quinoline-based drug candidates, including potential antimalarial and anticancer agents.
• Agrochemical Synthesis: Used in the development of advanced crop protection chemicals where the silylated aminoquinoline scaffold provides specific bioactivity.
• Organic Synthesis Reagent: Acts as a versatile building block and protecting group agent for amino and hydroxyl groups in multi-step synthetic routes.
• Material Science Research: Employed in the creation of functionalized organic molecules for optoelectronic materials and metal-organic frameworks (MOFs).
• Chemical Derivatization: Useful for analytical chemistry applications, such as derivatizing compounds for Gas Chromatography-Mass Spectrometry (GC-MS) analysis to improve volatility and detection.

Basic Information

Product Name	n-(Trimethylsilyl)-6-[(Trimethylsilyl)Oxy]-8-Quinolinamine
CAS No.	36972-87-9
Molecular Formula	C15H26N2OSi2
Molecular Weight	306.55 g/mol
Synonyms	8-Amino-N,6-bis(trimethylsilyl)quinoline; 8-Quinolinamine, N-(trimethylsilyl)-6-[(trimethylsilyl)oxy]-; 6,8-Bis(trimethylsilyloxy)quinoline (related); Bis-TMS-8-aminoquinoline; N,O-Bis(trimethylsilyl)-8-amino-6-hydroxyquinoline; 8-Aminoquinoline N,O-bis(trimethylsilyl) ether; TMS-protected 8-amino-6-hydroxyquinoline
EINECS	Contact for details

Quality Control

Our n-(Trimethylsilyl)-6-[(Trimethylsilyl)Oxy]-8-Quinolinamine is produced under strict quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency, meeting the stringent requirements for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), appearance, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.