Description

Ent-Estradiol 3-Benzoate is a specific stereoisomer of estradiol benzoate, a well-characterized estrogen ester. This compound is of significant interest in pharmaceutical research and development, particularly for studying structure-activity relationships and metabolic pathways of steroid hormones. It serves as a critical reference standard and a key synthetic intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity, well-defined steroid derivatives.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in steroid hormone analysis.
• Biochemical Research: Employed in metabolic studies, receptor binding assays, and pharmacological research to investigate estrogenic activity and stereospecific effects.
• Fine Chemical Synthesis: Acts as a crucial chiral building block or intermediate in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and novel chemical entities.
• Academic Research: Utilized in university and institutional labs for fundamental studies in endocrinology, medicinal chemistry, and organic synthesis.
• Analytical Testing Services: Serves as a high-purity standard for contract research organizations (CROs) and testing laboratories performing HPLC, GC-MS, or other chromatographic analyses.

Basic Information

Product Name	Ent-Estradiol 3-Benzoate
CAS No.	36952-50-8
Molecular Formula	C25H28O3
Molecular Weight	376.49 g/mol
Synonyms	Ent-Estradiol Benzoate; (8R,9S,13S,14S)-13-Methyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol 3-benzoate; 17β-Estradiol 3-benzoate enantiomer; Estra-1,3,5(10)-triene-3,17β-diol 3-benzoate (ent-form); Benzoic acid, (8R,9S,13S,14S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthren-6-yl ester
EINECS	Contact for details

Quality Control

Our Ent-Estradiol 3-Benzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR), purity assessment by HPLC, and determination of specific optical rotation. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Specific Optical Rotation	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.