Description

(1-Phenyl-1-Tosyl)Methyl Isocyanide is a specialized organic building block featuring both phenyl and tosyl protecting groups on the isocyanide functionality. This compound is valued for its role as a versatile synthon in multi-component reactions and heterocyclic synthesis, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for lead optimization and the development of novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nitrogen-containing heterocycles, which are core scaffolds in many active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides through structure-activity relationship (SAR) studies.
• Material Science: Serves as a building block for creating functionalized polymers and organic electronic materials.
• Academic & R&D: Employed in methodological development for novel isocyanide-based multi-component reactions (MCRs) like the Ugi and Passerini reactions.
• Chemical Biology: Useful as a probe or labeling agent due to the reactive isocyanide group, facilitating bioconjugation strategies.
• Catalyst Ligand Synthesis: Acts as a precursor for constructing sophisticated ligand systems used in homogeneous catalysis.

Basic Information

Product Name	(1-Phenyl-1-Tosyl)Methyl Isocyanide
CAS No.	36635-66-2
Molecular Formula	C15H13NO2S
Molecular Weight	271.33 g/mol
Synonyms	[(Tosyl)(phenyl)methyl]isocyanide; (Phenyl-p-toluenesulfonylmethyl)isocyanide; 1-Isocyano-1-phenyl-1-tosylmethane; α-Isocyano-α-phenyl-p-tolylsulfonylmethane; (Phenyl-tosyl-methyl)isocyanide; N-[(Phenyl)(tosyl)methyl]formimidoyl; Tosyl(phenyl)methyl isocyanide; p-Toluenesulfonyl(phenyl)methyl isocyanide
EINECS	Contact for details

Quality Control

Our (1-Phenyl-1-Tosyl)Methyl Isocyanide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.