Description

Phenylsulfonylmethyl Isocyanide is a versatile and highly reactive organic building block, primarily valued for its role as a key reagent in multicomponent reactions. Its unique structure, featuring both an isocyanide and a phenylsulfonyl group, makes it indispensable for the efficient synthesis of complex heterocyclic scaffolds and functionalized molecules. This compound is particularly sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel compound libraries and active ingredients.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of diverse nitrogen-containing heterocycles, such as imidazoles and oxazoles, which are core structures in many drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides by enabling the construction of complex molecular architectures.
• Material Science Research: Employed in the preparation of functional organic materials and ligands for catalysis.
• Ugi Reaction & Multicomponent Chemistry: Serves as a fundamental isocyanide component in Ugi and Passerini reactions, facilitating rapid and atom-economical synthesis of peptide-like structures and amide derivatives.
• Chemical Biology & Probe Development: Utilized for the site-specific labeling and modification of biomolecules or in the creation of activity-based probes.
• Academic & Process R&D: A valuable tool for methodological development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	Phenylsulfonylmethyl Isocyanide
CAS No.	36635-63-9
Molecular Formula	C8H7NO2S
Molecular Weight	181.21 g/mol
Synonyms	Tosylmethyl Isocyanide (TosMIC); (Isocyanomethyl)sulfonylbenzene; Phenyl[(isocyanomethyl)sulfonyl]methane; α-Isocyano-p-toluenesulfonylmethane; p-Toluenesulfonylmethyl Isocyanide; TOSMIC Reagent; 1-Isocyano-1-(phenylsulfonyl)methane
EINECS	Contact for details

Quality Control

Our Phenylsulfonylmethyl Isocyanide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	115 - 120 °C
Loss on Drying	≤ 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.