Description

Tosylmethyl Isocyanide (TosMIC) is a versatile and highly valuable reagent in organic synthesis, renowned for its role as a one-carbon building block. Its primary significance lies in facilitating the synthesis of heterocyclic compounds, including oxazoles, imidazoles, and pyrroles, through reactions like the Van Leusen reaction. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries developing novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediates: A key synthon for constructing nitrogen-containing heterocycles, which are core structures in many drug molecules.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides that incorporate heterocyclic frameworks.
• Fine Chemical Manufacturing: Employed in the synthesis of dyes, pigments, and advanced materials requiring specific heterocyclic components.
• Academic & R&D: A fundamental reagent in methodological development and the synthesis of complex natural products or novel chemical entities.
• Peptide Mimetics: Useful in the preparation of compounds that mimic peptide structures for biochemical research.

Basic Information

Product Name	Tosylmethyl Isocyanide
CAS No.	36635-61-7
Molecular Formula	C9H9NO2S
Molecular Weight	195.24 g/mol
Synonyms	TosMIC; p-Toluenesulfonylmethyl isocyanide; 4-Methylbenzenesulfonylmethyl isocyanide; (Isocyanomethyl)sulfonylbenzene; Toluenesulfonylmethyl isonitrile; NSC 253978; Tosyl methyl isocyanide
EINECS	Contact for details

Quality Control

Our Tosylmethyl Isocyanide is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to guarantee reliable supply and product integrity for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in the original packaging or amber glass until use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Melting Point	114 - 118 °C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.