Description

tert-Butyl α-Hydroxyisobutyrate is a high-purity specialty ester, valued as a versatile intermediate and protecting group reagent in advanced organic synthesis. Its unique structure, featuring both a tert-butyl ester and an α-hydroxy group, makes it a critical building block for constructing complex molecules with high stereochemical control. This compound is essential for research and production in the pharmaceutical, agrochemical, and fine chemical industries, where it facilitates the synthesis of active pharmaceutical ingredients (APIs) and other high-value compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon and protecting group reagent in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where its structural motif contributes to biological activity.
• Fine Chemical Manufacturing: Serves as a crucial building block for fragrances, flavors, and other specialty organic compounds requiring high purity.
• Polymer Chemistry: Acts as a monomer or chain transfer agent in the synthesis of specialized polymers with tailored properties.
• Academic & Industrial R&D: Employed in research laboratories for method development and the exploration of new synthetic pathways.
• Peptide Chemistry: Utilized for the temporary protection of carboxylic acid groups during solid-phase and solution-phase peptide synthesis.

Basic Information

Product Name	tert-Butyl α-Hydroxyisobutyrate
CAS No.	36293-63-7
Molecular Formula	C8H16O3
Molecular Weight	160.21 g/mol
Synonyms	2-Hydroxy-2-methylpropanoic acid tert-butyl ester; tert-Butyl 2-hydroxy-2-methylpropionate; 2-Methyl-2-(tert-butoxycarbonyl)propanoic acid; α-Hydroxyisobutyric acid tert-butyl ester; TBHIB; t-Butyl α-hydroxyisobutyrate
EINECS	Contact for details

Quality Control

Our tert-Butyl α-Hydroxyisobutyrate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical pharmaceutical and fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and oxidizing agents. The container should be kept tightly sealed when not in use to prevent moisture absorption and maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.410 - 1.420
Specific Gravity (20°C)	0.950 - 0.980

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.