Description

Halofantrine Hydrochloride is a synthetic antimalarial agent belonging to the phenanthrenemethanol class. It is valued for its activity against chloroquine-resistant strains of *Plasmodium falciparum*, making it a critical compound in parasitology research and pharmaceutical development. This high-purity chemical is essential for researchers, reference standard producers, and manufacturers in the global pharmaceutical and life sciences industries.

Application

• Pharmaceutical Active Ingredient (API): Serves as the core component in the formulation of antimalarial medications.
• Biomedical Research: Used as a reference standard and investigational compound in parasitology studies, particularly for drug resistance mechanisms.
• Analytical Chemistry: Employed as a certified reference material (CRM) for method development and quality control testing in laboratories.
• Drug Discovery & Development: Acts as a lead compound or pharmacophore model for synthesizing novel antiparasitic agents.
• Academic & Clinical Studies: Utilized in universities and research institutes for in vitro and in vivo efficacy testing against malaria parasites.

Basic Information

Product Name	Halofantrine Hydrochloride
CAS No.	36167-63-2
Molecular Formula	C26H30Cl2F3NO • HCl
Molecular Weight	536.89 g/mol (for hydrochloride salt)
Synonyms	Halofantrine HCl; (±)-Halofantrine Hydrochloride; 1,3-Dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol Hydrochloride; WR-171,669 Hydrochloride; Halfan (brand name derivative); Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, hydrochloride; Halofantrinium Chloride
EINECS	Contact for details

Quality Control

Our Halofantrine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.