Description

3',5'-Di-o-Benzoylthymidine is a key protected nucleoside derivative, specifically a thymidine molecule where the 3' and 5' hydroxyl groups are benzoylated. This chemical modification is critical for its primary role as a vital synthetic intermediate in oligonucleotide and nucleoside analog synthesis. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing antiviral drugs, anticancer agents, and novel therapeutic oligonucleotides.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex nucleoside-based active pharmaceutical ingredients (APIs).
• Oligonucleotide Synthesis: Used in solid-phase phosphoramidite chemistry for the controlled assembly of DNA and RNA strands.
• Antiviral Drug Development: Serves as a precursor in the manufacture of thymidine-analog reverse transcriptase inhibitors and other antiviral compounds.
• Anticancer Agent Research: Employed in the creation of novel nucleoside analogs that target cancer cell proliferation.
• Biochemical Research: Utilized in academic and industrial labs for studying nucleic acid chemistry, enzyme mechanisms, and metabolic pathways.
• Prodrug Synthesis: Acts as a protected form of thymidine for developing prodrugs with enhanced bioavailability.

Basic Information

Product Name	3',5'-Di-o-Benzoylthymidine
CAS No.	35898-30-7
Molecular Formula	C25H22N2O7
Molecular Weight	462.45 g/mol
Synonyms	3',5'-Di-O-benzoylthymidine; 1-[(2R,4S,5R)-4-Benzoyloxy-5-(benzoyloxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione; Thymidine 3',5'-dibenzoate; 2'-Deoxythymidine 3',5'-dibenzoate; NSC 122047; 3',5'-Di-O-benzoyl-2'-deoxythymidine; 3',5'-Dibenzoylthymidine
EINECS	Contact for details

Quality Control

Our 3',5'-Di-o-Benzoylthymidine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.