Description

Ethyl n-[3-[Bis(2-Chloroethyl)Amino]-3-Phenyl-n-L-Prolyl-L-Alanyl]-4-Fluoro-3-Phenyl-L-Alaninate Monohydrochloride is a complex, high-purity synthetic peptide derivative designed for advanced research and development. This compound is of significant interest in the pharmaceutical and biotechnology sectors due to its sophisticated molecular architecture, which incorporates a nitrogen mustard moiety and fluorinated phenylalanine residues. It serves as a critical building block or reference standard for medicinal chemists and researchers developing novel therapeutic agents, particularly in oncology and targeted drug delivery. Its precise synthesis and characterization are essential for ensuring the efficacy and safety of next-generation pharmaceutical candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel peptide-based drug candidates, especially those targeting specific cellular pathways.
• Medicinal Chemistry Research: Used as a reference compound or a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Oncological Research: Serves as a model compound for investigating alkylating agent conjugates and prodrug strategies due to the presence of the bis(2-chloroethyl)amino group.
• Bioconjugation Studies: Employed in developing targeted therapies where the peptide sequence is used for specific receptor binding.
• Process Development & Scale-up: Acts as a benchmark for optimizing synthetic routes and purification processes in API (Active Pharmaceutical Ingredient) manufacturing.
• Analytical Standard: Provides a high-purity reference material for quality control (QC) and analytical method development (HPLC, MS) in regulatory submissions.

Basic Information

Product Name	Ethyl n-[3-[Bis(2-Chloroethyl)Amino]-3-Phenyl-n-L-Prolyl-L-Alanyl]-4-Fluoro-3-Phenyl-L-Alaninate Monohydrochloride
CAS No.	35849-47-9
Molecular Formula	C₃₃H₄₄Cl₃FN₄O₅
Molecular Weight	702.08 g/mol
Synonyms	NSC 357704; Ethyl N-[3-[bis(2-chloroethyl)amino]-3-phenyl-DL-prolyl-L-alanyl]-4-fluoro-3-phenylalaninate monohydrochloride; 4-Fluoro-3-phenyl-L-alanine, N-[3-[bis(2-chloroethyl)amino]-3-phenyl-DL-prolyl]-, ethyl ester, monohydrochloride; L-Alanine, N-[3-[bis(2-chloroethyl)amino]-3-phenyl-DL-prolyl]-, ethyl ester, 4-fluoro-3-phenyl-, monohydrochloride; Ethyl (2S)-2-[[(2S)-1-[(2S)-2-[[3-[bis(2-chloroethyl)amino]-3-phenylprolyl]amino]propanoyl]pyrrolidin-2-yl]carbamoyl]-2-(4-fluoro-3-phenyl)acetate hydrochloride
EINECS	Contact for details

Quality Control

Our Ethyl n-[3-[Bis(2-Chloroethyl)Amino]-3-Phenyl-n-L-Prolyl-L-Alanyl]-4-Fluoro-3-Phenyl-L-Alaninate Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) that include data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with the standards expected for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.