Description

Ethyl N2-[3-[Bis(2-Chloroethyl)Amino]-n-(4-Fluoro-3-Phenyl-L-Alanyl)-3-Phenyl-L-Alanyl]-L-Asparaginate Monohydrochloride is a sophisticated, high-purity synthetic peptide derivative designed for advanced research and development. This compound is critical for its role as a key intermediate or reference standard in the development of novel therapeutic agents, particularly in oncology and targeted drug delivery. It is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on peptide-based drug discovery and mechanism-of-action studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex peptide-based anticancer agents and targeted therapies.
• Biochemical Research: Used as a reference standard or probe in studies investigating enzyme inhibition, receptor binding, and cellular signaling pathways.
• Drug Discovery & Development: A key material for medicinal chemists in the design, optimization, and structure-activity relationship (SAR) studies of novel drug candidates.
• Oncology Research: Investigated for its potential role in developing compounds that interfere with DNA alkylation or specific protein-protein interactions.
• Peptide Chemistry: Employed in advanced peptide synthesis for introducing specific functional groups or creating complex peptide conjugates.
• Analytical Standard: Provides a high-purity benchmark for quality control and method validation in analytical laboratories using HPLC, LC-MS, or NMR.

Basic Information

Item	Detail
Product Name	Ethyl N2-[3-[Bis(2-Chloroethyl)Amino]-n-(4-Fluoro-3-Phenyl-L-Alanyl)-3-Phenyl-L-Alanyl]-L-Asparaginate Monohydrochloride
CAS No.	35849-45-7
Molecular Formula	C33H44Cl2FN5O6 • HCl
Molecular Weight	712.10 g/mol (Free base: 676.62 g/mol)
Synonyms	Ethyl L-Asparaginate, N-[3-[bis(2-chloroethyl)amino]-N-(N-4-fluoro-3-phenyl-L-alanyl)-3-phenyl-L-alanyl]-, monohydrochloride; L-Aspartic acid, N-[N-[3-[bis(2-chloroethyl)amino]-N-(N-4-fluoro-3-phenylalanyl)-3-phenylalanyl]]-, ethyl ester, hydrochloride (1:1); 4-Fluoro-3-phenyl-L-alanine derivative; Peptide alkylating agent intermediate; Melphalan peptide analog intermediate
EINECS	Contact for details

Quality Control

Our Ethyl N2-[3-[Bis(2-Chloroethyl)Amino]-n-(4-Fluoro-3-Phenyl-L-Alanyl)-3-Phenyl-L-Alanyl]-L-Asparaginate Monohydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >95% by HPLC), and impurity profiles. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D, with testing performed using validated analytical methods including HPLC, MS, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with molecular structure
Purity (HPLC)	≥ 95.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.