Description

tert-Butyl 5-Oxo-L-Prolinate is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block for the construction of complex molecules, offering significant value in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries for peptide synthesis and medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates and Active Pharmaceutical Ingredients (APIs).
• Peptide Chemistry: Used as a protected proline derivative in solid-phase and solution-phase peptide synthesis.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the development of novel therapeutic compounds.
• Asymmetric Synthesis: Serves as a precursor for catalysts or ligands used in stereoselective transformations.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals requiring high enantiomeric purity.
• Bioconjugation: Potential use in the modification of biomolecules for diagnostic or therapeutic purposes.

Basic Information

Product Name	tert-Butyl 5-Oxo-L-Prolinate
CAS No.	35418-16-7
Molecular Formula	C9H15NO3
Molecular Weight	185.22 g/mol
Synonyms	L-Pyroglutamic acid tert-butyl ester; (S)-5-Oxo-2-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl L-pyroglutamate; (S)-tert-Butyl 5-oxopyrrolidine-2-carboxylate; 5-Oxo-L-proline tert-butyl ester; Boc-5-oxo-L-Pro-OH (common abbreviation); L-Pyroglutamic acid t-butyl ester; 2-Pyrrolidinecarboxylic acid, 5-oxo-, 1,1-dimethylethyl ester, (S)-
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Oxo-L-Prolinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with every shipment to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.