Description

1-Methyl-2-(Trimethylsilyl) Imidazole is a versatile organosilicon-protected imidazole derivative, serving as a critical building block and reagent in advanced organic synthesis. Its value lies in its dual functionality, offering both the reactivity of an imidazole ring and the protective and modifying properties of a silyl group. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise control over molecular architecture and reaction pathways.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for compounds containing imidazole or purine-like scaffolds.
• Agrochemical Synthesis: Used in the production of advanced fungicides, herbicides, and plant growth regulators where the silylated imidazole moiety introduces specific biological activity.
• Ligand and Catalyst Precursor: Serves as a precursor for N-heterocyclic carbene (NHC) ligands and other organocatalysts used in transition metal catalysis and asymmetric synthesis.
• Silylating Agent: Employed to introduce the trimethylsilyl (TMS) protecting group onto sensitive heterocycles or other nucleophiles under mild conditions.
• Material Science Research: Utilized in the synthesis of novel ionic liquids, conductive polymers, and metal-organic frameworks (MOFs) with tailored properties.
• Nucleoside and Nucleotide Chemistry: Acts as a protected intermediate in the synthesis of modified nucleosides and related bioactive molecules.

Basic Information

Product Name	1-Methyl-2-(Trimethylsilyl) Imidazole
CAS No.	35342-89-3
Molecular Formula	C7H14N2Si
Molecular Weight	154.29 g/mol
Synonyms	1-Methyl-2-(trimethylsilyl)-1H-imidazole; 2-(Trimethylsilyl)-1-methylimidazole; N-Methyl-2-(trimethylsilyl)imidazole; 1-Methyl-2-trimethylsilylimidazole; TMS-Methylimidazole; 1H-Imidazole, 1-methyl-2-(trimethylsilyl)-; 2-Trimethylsilyl-1-methylimidazole
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity intermediates. Each batch is analyzed using advanced techniques including GC, HPLC, and NMR to confirm identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are available upon request. We adhere to a quality management system to guarantee supply reliability and product integrity for your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.